Drug interactions
Clevidipine + Esmolol
Severity: Moderate
Clevidipine and Esmolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower blood pressure, so combined use can cause additive hypotension. Clevidipine may cause reflex tachycardia that esmolol blunts, which is often intentional in perioperative hypertension. Excessive hypotension is the main concern.
What this interaction means in plain words
Clevidipine and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clevidipine belongs to Cardiovascular; Esmolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects from arterial vasodilation by calcium channel blockade and negative chronotropy/inotropy from beta-blockade.
What to do
Titrate each infusion to blood pressure and heart rate targets with continuous hemodynamic monitoring. Reduce one or both rates if hypotension or bradycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Clevidipine
Frequently asked questions
Can I take Clevidipine with Esmolol?
MediHelp rates the interaction as moderate. Clevidipine and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents lower blood pressure, so combined use can cause additive hypotension. Clevidipine may cause reflex tachycardia that esmolol blunts, which is often intentional in perioperative hypertension. Excessive hypotension is the main concern.
How serious is the interaction between Clevidipine and Esmolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate each infusion to blood pressure and heart rate targets with continuous hemodynamic monitoring. Reduce one or both rates if hypotension or bradycardia develops.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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