Drug interactions
Clevidipine + Itraconazole
Severity: Moderate
Clevidipine and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole has negative inotropic effects and inhibits CYP3A4, and dihydropyridine calcium channel blockers can cause edema and heart failure aggravation. Clevidipine is cleared mainly by blood and tissue esterases, so pharmacokinetic interaction is limited, though additive hypotension and negative inotropy remain possible.
What this interaction means in plain words
Clevidipine and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clevidipine belongs to Cardiovascular; Itraconazole belongs to Anti Fungals.
Why it happens
Additive negative inotropic effects, with minimal CYP3A4-mediated pharmacokinetic influence for clevidipine.
What to do
Monitor blood pressure and signs of heart failure during infusion, and titrate clevidipine to effect, with extra care in patients with left ventricular dysfunction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Clevidipine
Frequently asked questions
Can I take Clevidipine with Itraconazole?
MediHelp rates the interaction as moderate. Clevidipine and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole has negative inotropic effects and inhibits CYP3A4, and dihydropyridine calcium channel blockers can cause edema and heart failure aggravation. Clevidipine is cleared mainly by blood and tissue esterases, so pharmacokinetic interaction is limited, though additive hypotension and negative inotropy remain possible.
How serious is the interaction between Clevidipine and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and signs of heart failure during infusion, and titrate clevidipine to effect, with extra care in patients with left ventricular dysfunction.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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