Drug interactions
Clevidipine + Labetalol
Severity: Moderate
Clevidipine and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure and are often used together in acute hypertension. Excessive hypotension or reflex changes in heart rate may occur.
What this interaction means in plain words
Clevidipine and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clevidipine belongs to Cardiovascular; Labetalol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects through calcium channel blockade vasodilation and alpha/beta-blockade.
What to do
Titrate clevidipine to blood pressure with continuous monitoring and adjust labetalol dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Clevidipine
Frequently asked questions
Can I take Clevidipine with Labetalol?
MediHelp rates the interaction as moderate. Clevidipine and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure and are often used together in acute hypertension. Excessive hypotension or reflex changes in heart rate may occur.
How serious is the interaction between Clevidipine and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate clevidipine to blood pressure with continuous monitoring and adjust labetalol dose accordingly.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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