Drug interactions
Clevidipine + Mefloquine
Severity: Minor
Clevidipine and Mefloquine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefloquine has cardiac conduction effects and clevidipine lowers blood pressure, so combined hemodynamic effects are possible. Clevidipine is cleared by blood esterases rather than CYP enzymes, so no meaningful metabolic interaction is expected.
What this interaction means in plain words
Clevidipine and Mefloquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clevidipine belongs to Cardiovascular; Mefloquine belongs to Anti Parasitic.
Why it happens
Possible additive cardiovascular effects; no established pharmacokinetic mechanism.
What to do
Monitor blood pressure and heart rate during clevidipine infusion. No dose change is needed routinely.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Clevidipine
Frequently asked questions
Can I take Clevidipine with Mefloquine?
MediHelp rates the interaction as minor. Clevidipine and Mefloquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mefloquine has cardiac conduction effects and clevidipine lowers blood pressure, so combined hemodynamic effects are possible. Clevidipine is cleared by blood esterases rather than CYP enzymes, so no meaningful metabolic interaction is expected.
How serious is the interaction between Clevidipine and Mefloquine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during clevidipine infusion. No dose change is needed routinely.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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