Drug interactions
Clevidipine + Succinylcholine
Severity: Minor
Clevidipine and Succinylcholine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers may potentiate neuromuscular blockers and prolong blockade. With clevidipine, a short-acting intravenous agent, the clinical effect on succinylcholine is probably small.
What this interaction means in plain words
Clevidipine and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clevidipine belongs to Cardiovascular; Succinylcholine belongs to Musculoskeletal.
Why it happens
Calcium channel blockade may reduce prejunctional acetylcholine release, modestly enhancing neuromuscular blockade.
What to do
Monitor neuromuscular recovery with a nerve stimulator when used together. Titrate muscle relaxant dosing to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Succinylcholine
Other interactions of Clevidipine
Frequently asked questions
Can I take Clevidipine with Succinylcholine?
MediHelp rates the interaction as minor. Clevidipine and Succinylcholine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers may potentiate neuromuscular blockers and prolong blockade. With clevidipine, a short-acting intravenous agent, the clinical effect on succinylcholine is probably small.
How serious is the interaction between Clevidipine and Succinylcholine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular recovery with a nerve stimulator when used together. Titrate muscle relaxant dosing to response.
What other medicines interact with Succinylcholine?
MediHelp also lists interactions of Succinylcholine with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Succinylcholine page.
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