Drug interactions
Clobazam + Clomipramine
Severity: Moderate
Clobazam and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam and its active metabolite can inhibit CYP2D6 weakly to moderately, which may raise clomipramine and its metabolite exposure. Both drugs also depress the CNS, so sedation and psychomotor impairment can be additive.
What this interaction means in plain words
Clobazam and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Clomipramine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by clobazam plus additive CNS depression.
What to do
Monitor for excessive sedation and tricyclic adverse effects, and lower the clomipramine dose if they occur. Counsel patients about driving and operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Clomipramine?
MediHelp rates the interaction as moderate. Clobazam and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam and its active metabolite can inhibit CYP2D6 weakly to moderately, which may raise clomipramine and its metabolite exposure. Both drugs also depress the CNS, so sedation and psychomotor impairment can be additive.
How serious is the interaction between Clobazam and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and tricyclic adverse effects, and lower the clomipramine dose if they occur. Counsel patients about driving and operating machinery.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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