Drug interactions
Clobazam + Clorazepate
Severity: Moderate
Clobazam and Clorazepate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two benzodiazepines together leads to additive sedation, psychomotor impairment and respiratory depression. Clorazepate's active metabolite nordazepam is also a substrate of CYP2C19 and shares pathways with clobazam's metabolite.
What this interaction means in plain words
Clobazam and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Clorazepate belongs to Central Nervous System.
Why it happens
Additive GABA-A receptor potentiation producing CNS depression.
What to do
Monitor for sedation and respiratory depression and use the lowest effective combined dose. If used for epilepsy, watch for tolerance and reassess the need for both agents.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Clorazepate?
MediHelp rates the interaction as moderate. Clobazam and Clorazepate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using two benzodiazepines together leads to additive sedation, psychomotor impairment and respiratory depression. Clorazepate's active metabolite nordazepam is also a substrate of CYP2C19 and shares pathways with clobazam's metabolite.
How serious is the interaction between Clobazam and Clorazepate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression and use the lowest effective combined dose. If used for epilepsy, watch for tolerance and reassess the need for both agents.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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