Drug interactions
Clobazam + Eslicarbazepine
Severity: Moderate
Clobazam and Eslicarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation, so additive CNS effects are expected. Eslicarbazepine inhibits CYP2C19, which may raise levels of clobazam's active metabolite N-desmethylclobazam, while CYP3A4 induction could lower clobazam itself.
What this interaction means in plain words
Clobazam and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Eslicarbazepine belongs to Central Nervous System.
Why it happens
Additive CNS depression plus CYP2C19 inhibition and CYP3A4 induction by eslicarbazepine altering clobazam disposition.
What to do
Monitor for sedation, ataxia, and seizure control, and adjust the clobazam dose according to response. Warn patients about driving and other hazardous activities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Eslicarbazepine?
MediHelp rates the interaction as moderate. Clobazam and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation, so additive CNS effects are expected. Eslicarbazepine inhibits CYP2C19, which may raise levels of clobazam's active metabolite N-desmethylclobazam, while CYP3A4 induction could lower clobazam itself.
How serious is the interaction between Clobazam and Eslicarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, ataxia, and seizure control, and adjust the clobazam dose according to response. Warn patients about driving and other hazardous activities.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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