Drug interactions
Clobazam + Ethinyl estradiol-drospirenone
Severity: Moderate
Clobazam and Ethinyl estradiol-drospirenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a weak CYP3A4 inducer and may lower concentrations of ethinyl estradiol and drospirenone. Hormonal contraceptive effectiveness may be reduced, and unintended pregnancy is a concern in women on antiseizure medication.
What this interaction means in plain words
Clobazam and Ethinyl estradiol-drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Ethinyl estradiol-drospirenone belongs to Endocrine.
Why it happens
Weak induction of CYP3A4 increases the metabolism of the contraceptive hormones.
What to do
Recommend an additional non-hormonal contraceptive method during clobazam therapy and for a period after discontinuation. Monitor for breakthrough bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as moderate. Clobazam and Ethinyl estradiol-drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam is a weak CYP3A4 inducer and may lower concentrations of ethinyl estradiol and drospirenone. Hormonal contraceptive effectiveness may be reduced, and unintended pregnancy is a concern in women on antiseizure medication.
How serious is the interaction between Clobazam and Ethinyl estradiol-drospirenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Recommend an additional non-hormonal contraceptive method during clobazam therapy and for a period after discontinuation. Monitor for breakthrough bleeding.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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