Drug interactions
Clobazam + Etonogestrel
Severity: Moderate
Clobazam and Etonogestrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a weak CYP3A4 inducer and may modestly reduce hormonal contraceptive exposure. Efficacy of the implant could be diminished, particularly with higher clobazam doses.
What this interaction means in plain words
Clobazam and Etonogestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Etonogestrel belongs to Endocrine.
Why it happens
Weak induction of CYP3A4 by clobazam increases etonogestrel clearance.
What to do
Recommend an additional non-hormonal contraceptive method during clobazam therapy and for a period after stopping.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etonogestrel
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Etonogestrel?
MediHelp rates the interaction as moderate. Clobazam and Etonogestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam is a weak CYP3A4 inducer and may modestly reduce hormonal contraceptive exposure. Efficacy of the implant could be diminished, particularly with higher clobazam doses.
How serious is the interaction between Clobazam and Etonogestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Recommend an additional non-hormonal contraceptive method during clobazam therapy and for a period after stopping.
What other medicines interact with Etonogestrel?
MediHelp also lists interactions of Etonogestrel with, for example, Amobarbital, Armodafinil, Bosentan. The full list is on the Etonogestrel page.
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