Drug interactions
Clobazam + Fluphenazine
Severity: Moderate
Clobazam and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause CNS depression, so the combination can increase sedation, impaired coordination and respiratory depression. Clobazam may also modestly raise exposure to CYP2D6 substrates such as fluphenazine.
What this interaction means in plain words
Clobazam and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression, plus weak CYP2D6 inhibition by clobazam.
What to do
Monitor sedation and extrapyramidal effects, and reduce the fluphenazine dose if adverse effects emerge. Counsel patients on impaired driving ability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Fluphenazine?
MediHelp rates the interaction as moderate. Clobazam and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause CNS depression, so the combination can increase sedation, impaired coordination and respiratory depression. Clobazam may also modestly raise exposure to CYP2D6 substrates such as fluphenazine.
How serious is the interaction between Clobazam and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and extrapyramidal effects, and reduce the fluphenazine dose if adverse effects emerge. Counsel patients on impaired driving ability.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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