Drug interactions
Clobazam + Fluvoxamine
Severity: Moderate
Clobazam and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvoxamine inhibits CYP2C19 and CYP3A4, which can raise levels of the active metabolite N-desmethylclobazam and increase sedation and psychomotor impairment. Clobazam is a weak CYP2D6 inhibitor, which may modestly raise fluvoxamine exposure.
What this interaction means in plain words
Clobazam and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Fluvoxamine belongs to Central Nervous System.
Why it happens
Fluvoxamine inhibits CYP2C19 (and CYP3A4) metabolism of clobazam and its metabolite, and clobazam weakly inhibits CYP2D6.
What to do
Monitor for excessive sedation, ataxia and cognitive effects, and reduce the clobazam dose if they occur. Consider a lower starting dose of clobazam when fluvoxamine is used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Fluvoxamine?
MediHelp rates the interaction as moderate. Clobazam and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvoxamine inhibits CYP2C19 and CYP3A4, which can raise levels of the active metabolite N-desmethylclobazam and increase sedation and psychomotor impairment. Clobazam is a weak CYP2D6 inhibitor, which may modestly raise fluvoxamine exposure.
How serious is the interaction between Clobazam and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, ataxia and cognitive effects, and reduce the clobazam dose if they occur. Consider a lower starting dose of clobazam when fluvoxamine is used.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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