Drug interactions
Clobazam + Haloperidol
Severity: Moderate
Clobazam and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a weak CYP2D6 inhibitor and haloperidol is partly metabolized by CYP2D6, so haloperidol levels may rise modestly. Both also cause sedation, so combined use may add to CNS depression.
What this interaction means in plain words
Clobazam and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Haloperidol belongs to Central Nervous System.
Why it happens
Weak CYP2D6 inhibition by clobazam and additive CNS depression.
What to do
Monitor for haloperidol adverse effects such as extrapyramidal symptoms and sedation, and reduce the haloperidol dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Haloperidol?
MediHelp rates the interaction as moderate. Clobazam and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam is a weak CYP2D6 inhibitor and haloperidol is partly metabolized by CYP2D6, so haloperidol levels may rise modestly. Both also cause sedation, so combined use may add to CNS depression.
How serious is the interaction between Clobazam and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for haloperidol adverse effects such as extrapyramidal symptoms and sedation, and reduce the haloperidol dose if needed.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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