Drug interactions
Clobazam + Norethisterone
Severity: Moderate
Clobazam and Norethisterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a weak CYP3A4 inducer and may reduce hormonal contraceptive exposure. Contraceptive efficacy could be diminished, particularly with lower-dose pills.
What this interaction means in plain words
Clobazam and Norethisterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Norethisterone belongs to Endocrine.
Why it happens
Weak induction of CYP3A4 by clobazam increases norethisterone clearance.
What to do
Recommend an additional non-hormonal contraceptive method while on clobazam and for a period after stopping. Consider a method not affected by enzyme induction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Norethisterone
- Acitretin + Norethisterone Contraindicated
- Amobarbital + Norethisterone Major
- Apalutamide + Norethisterone Major
- Belzutifan + Norethisterone Major
- Bosentan + Norethisterone Major
- Brigatinib + Norethisterone Major
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Norethisterone?
MediHelp rates the interaction as moderate. Clobazam and Norethisterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam is a weak CYP3A4 inducer and may reduce hormonal contraceptive exposure. Contraceptive efficacy could be diminished, particularly with lower-dose pills.
How serious is the interaction between Clobazam and Norethisterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Recommend an additional non-hormonal contraceptive method while on clobazam and for a period after stopping. Consider a method not affected by enzyme induction.
What other medicines interact with Norethisterone?
MediHelp also lists interactions of Norethisterone with, for example, Acitretin, Amobarbital, Apalutamide. The full list is on the Norethisterone page.
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