Drug interactions
Clobazam + Omeprazole
Severity: Moderate
Clobazam and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omeprazole inhibits CYP2C19, which converts the active metabolite N-desmethylclobazam into inactive products. Exposure to this active metabolite can rise, increasing sedation, drowsiness and other CNS adverse effects.
What this interaction means in plain words
Clobazam and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Omeprazole inhibits CYP2C19, reducing clearance of N-desmethylclobazam, the active metabolite of clobazam.
What to do
Monitor for excess sedation and other CNS effects when omeprazole is started or stopped. Reduce the clobazam dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Omeprazole?
MediHelp rates the interaction as moderate. Clobazam and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omeprazole inhibits CYP2C19, which converts the active metabolite N-desmethylclobazam into inactive products. Exposure to this active metabolite can rise, increasing sedation, drowsiness and other CNS adverse effects.
How serious is the interaction between Clobazam and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and other CNS effects when omeprazole is started or stopped. Reduce the clobazam dose if adverse effects appear.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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