Drug interactions
Clobazam + Perphenazine
Severity: Moderate
Clobazam and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam, through its active metabolite, is a weak CYP2D6 inhibitor and may raise perphenazine concentrations, which depend heavily on CYP2D6. Both agents are sedating, so additive CNS depression is also likely.
What this interaction means in plain words
Clobazam and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
Weak CYP2D6 inhibition by clobazam reduces perphenazine metabolism, plus additive CNS depression.
What to do
Monitor for sedation, extrapyramidal effects and hypotension, and consider a lower perphenazine dose. Advise avoiding alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Perphenazine?
MediHelp rates the interaction as moderate. Clobazam and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam, through its active metabolite, is a weak CYP2D6 inhibitor and may raise perphenazine concentrations, which depend heavily on CYP2D6. Both agents are sedating, so additive CNS depression is also likely.
How serious is the interaction between Clobazam and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, extrapyramidal effects and hypotension, and consider a lower perphenazine dose. Advise avoiding alcohol and other sedatives.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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