Drug interactions
Clobazam + Tizanidine
Severity: Moderate
Clobazam and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause CNS depression, so using them together can increase drowsiness, dizziness and weakness. Higher doses or additional sedatives raise the risk of respiratory depression.
What this interaction means in plain words
Clobazam and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Tizanidine belongs to Musculoskeletal.
Why it happens
Additive CNS depression from the benzodiazepine's GABA-A potentiation and tizanidine's central alpha-2 agonism.
What to do
Use the lowest effective doses and monitor for oversedation and respiratory depression. Counsel patients to avoid alcohol and driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Tizanidine?
MediHelp rates the interaction as moderate. Clobazam and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause CNS depression, so using them together can increase drowsiness, dizziness and weakness. Higher doses or additional sedatives raise the risk of respiratory depression.
How serious is the interaction between Clobazam and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation and respiratory depression. Counsel patients to avoid alcohol and driving until the response is known.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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