Drug interactions
Clofarabine + Zidovudine
Severity: Moderate
Clofarabine and Zidovudine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zidovudine and clofarabine both cause bone marrow suppression. Together they may produce more severe neutropenia, anemia and thrombocytopenia.
What this interaction means in plain words
Clofarabine and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clofarabine belongs to Oncology; Zidovudine belongs to Anti Virals.
Why it happens
Additive myelosuppressive effects of the two agents.
What to do
Monitor complete blood counts closely and adjust or interrupt doses if marked cytopenias develop. Consider an antiretroviral alternative with less marrow toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clofarabine and Zidovudine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
Other interactions of Clofarabine
- Clofarabine + Siponimod Major
- Clofarabine + Tofacitinib Major
- Amlodipine-benazepril + Clofarabine Moderate
- Benazepril + Clofarabine Moderate
- Captopril-hydrochlorothiazide + Clofarabine Moderate
- Captopril + Clofarabine Moderate
Frequently asked questions
Can I take Clofarabine with Zidovudine?
MediHelp rates the interaction as moderate. Clofarabine and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zidovudine and clofarabine both cause bone marrow suppression. Together they may produce more severe neutropenia, anemia and thrombocytopenia.
How serious is the interaction between Clofarabine and Zidovudine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely and adjust or interrupt doses if marked cytopenias develop. Consider an antiretroviral alternative with less marrow toxicity.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel. The full list is on the Zidovudine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
