Drug interactions
Clofazimine + Gemifloxacin
Severity: Major
Clofazimine and Gemifloxacin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval and combined use may increase the risk of torsades de pointes. Clofazimine has a long half-life, so the effect can persist after discontinuation.
What this interaction means in plain words
Clofazimine and Gemifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clofazimine belongs to Anti Bacterial; Gemifloxacin belongs to Anti Bacterial.
Why it happens
Additive delay of cardiac repolarization via potassium channel effects.
What to do
Avoid combining where alternatives exist. If needed, perform baseline and follow-up ECGs and correct electrolyte abnormalities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Clofazimine
Frequently asked questions
Can I take Clofazimine with Gemifloxacin?
MediHelp rates the interaction as major. Clofazimine and Gemifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval and combined use may increase the risk of torsades de pointes. Clofazimine has a long half-life, so the effect can persist after discontinuation.
How serious is the interaction between Clofazimine and Gemifloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where alternatives exist. If needed, perform baseline and follow-up ECGs and correct electrolyte abnormalities.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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