Drug interactions
Clofazimine + Gilteritinib
Severity: Major
Clofazimine and Gilteritinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib prolongs the QT interval and clofazimine has also been linked to QT prolongation. Together they may increase the likelihood of serious ventricular arrhythmias, particularly in patients with other risk factors.
What this interaction means in plain words
Clofazimine and Gilteritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clofazimine belongs to Anti Bacterial; Gilteritinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation through effects on cardiac repolarization.
What to do
Perform an ECG at baseline and regularly during co-treatment, and keep potassium and magnesium within normal range. Reduce the gilteritinib dose or stop one agent if QTc rises substantially.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clofazimine
Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Frequently asked questions
Can I take Clofazimine with Gilteritinib?
MediHelp rates the interaction as major. Clofazimine and Gilteritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gilteritinib prolongs the QT interval and clofazimine has also been linked to QT prolongation. Together they may increase the likelihood of serious ventricular arrhythmias, particularly in patients with other risk factors.
How serious is the interaction between Clofazimine and Gilteritinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform an ECG at baseline and regularly during co-treatment, and keep potassium and magnesium within normal range. Reduce the gilteritinib dose or stop one agent if QTc rises substantially.
What other medicines interact with Clofazimine?
MediHelp also lists interactions of Clofazimine with, for example, Adagrasib, Amisulpride, Azithromycin. The full list is on the Clofazimine page.
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