Drug interactions
Clofazimine + Macimorelin
Severity: Moderate
Clofazimine and Macimorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin produces a small increase in QTc, and clofazimine also prolongs QT. Combining them could add to the risk of torsades de pointes during the diagnostic test.
What this interaction means in plain words
Clofazimine and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clofazimine belongs to Anti Bacterial; Macimorelin belongs to Endocrine.
Why it happens
Additive QT prolongation through cardiac repolarization effects.
What to do
Postpone macimorelin testing in patients taking clofazimine, or use an alternative diagnostic where practical. If testing is necessary, obtain an ECG and correct electrolytes first.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clofazimine
Other interactions of Macimorelin
Frequently asked questions
Can I take Clofazimine with Macimorelin?
MediHelp rates the interaction as moderate. Clofazimine and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macimorelin produces a small increase in QTc, and clofazimine also prolongs QT. Combining them could add to the risk of torsades de pointes during the diagnostic test.
How serious is the interaction between Clofazimine and Macimorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Postpone macimorelin testing in patients taking clofazimine, or use an alternative diagnostic where practical. If testing is necessary, obtain an ECG and correct electrolytes first.
What other medicines interact with Clofazimine?
MediHelp also lists interactions of Clofazimine with, for example, Adagrasib, Amisulpride, Azithromycin. The full list is on the Clofazimine page.
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