Drug interactions
Clofazimine + Osilodrostat
Severity: Moderate
Clofazimine and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osilodrostat can prolong the QT interval, and clofazimine carries a similar liability. The combination may raise the risk of arrhythmia, and osilodrostat-related hypokalemia can add further risk.
What this interaction means in plain words
Clofazimine and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clofazimine belongs to Anti Bacterial; Osilodrostat belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation through effects on cardiac repolarization.
What to do
Check ECG and serum potassium and magnesium at baseline and periodically during co-treatment. Correct electrolyte abnormalities promptly and reassess therapy if QTc lengthens significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clofazimine
Other interactions of Osilodrostat
Frequently asked questions
Can I take Clofazimine with Osilodrostat?
MediHelp rates the interaction as moderate. Clofazimine and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osilodrostat can prolong the QT interval, and clofazimine carries a similar liability. The combination may raise the risk of arrhythmia, and osilodrostat-related hypokalemia can add further risk.
How serious is the interaction between Clofazimine and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and serum potassium and magnesium at baseline and periodically during co-treatment. Correct electrolyte abnormalities promptly and reassess therapy if QTc lengthens significantly.
What other medicines interact with Clofazimine?
MediHelp also lists interactions of Clofazimine with, for example, Adagrasib, Amisulpride, Azithromycin. The full list is on the Clofazimine page.
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