Drug interactions
Clofazimine + Oxaliplatin
Severity: Moderate
Clofazimine and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin can prolong the QT interval and clofazimine has similar potential, so the combination may increase arrhythmia risk. Oxaliplatin-related diarrhea, vomiting and electrolyte loss can further heighten the risk.
What this interaction means in plain words
Clofazimine and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clofazimine belongs to Anti Bacterial; Oxaliplatin belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation; oxaliplatin does not have an established effect on clofazimine levels.
What to do
Monitor ECG at baseline and during treatment, and check potassium, magnesium and calcium regularly. Replace electrolytes promptly if chemotherapy causes losses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clofazimine
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Clofazimine with Oxaliplatin?
MediHelp rates the interaction as moderate. Clofazimine and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaliplatin can prolong the QT interval and clofazimine has similar potential, so the combination may increase arrhythmia risk. Oxaliplatin-related diarrhea, vomiting and electrolyte loss can further heighten the risk.
How serious is the interaction between Clofazimine and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG at baseline and during treatment, and check potassium, magnesium and calcium regularly. Replace electrolytes promptly if chemotherapy causes losses.
What other medicines interact with Clofazimine?
MediHelp also lists interactions of Clofazimine with, for example, Adagrasib, Amisulpride, Azithromycin. The full list is on the Clofazimine page.
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