Drug interactions
Clofazimine + Ribociclib
Severity: Major
Clofazimine and Ribociclib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both clofazimine and ribociclib prolong the QT interval in a dose-dependent manner. Used together they may add to the risk of torsades de pointes, particularly with electrolyte disturbances or other QT-prolonging drugs. Clofazimine has a very long half-life, so the effect persists after stopping.
What this interaction means in plain words
Clofazimine and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clofazimine belongs to Anti Bacterial; Ribociclib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarisation (QTc) from both drugs.
What to do
Avoid the combination if possible. If it is unavoidable, record a baseline ECG and monitor it regularly, correct potassium and magnesium, and reduce or stop ribociclib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clofazimine
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Clofazimine with Ribociclib?
MediHelp rates the interaction as major. Clofazimine and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both clofazimine and ribociclib prolong the QT interval in a dose-dependent manner. Used together they may add to the risk of torsades de pointes, particularly with electrolyte disturbances or other QT-prolonging drugs. Clofazimine has a very long half-life, so the effect persists after stopping.
How serious is the interaction between Clofazimine and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If it is unavoidable, record a baseline ECG and monitor it regularly, correct potassium and magnesium, and reduce or stop ribociclib if QTc becomes markedly prolonged.
What other medicines interact with Clofazimine?
MediHelp also lists interactions of Clofazimine with, for example, Adagrasib, Amisulpride, Azithromycin. The full list is on the Clofazimine page.
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