Drug interactions
Clomipramine + Daridorexant
Severity: Moderate
Clomipramine and Daridorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause CNS depression, so concurrent use can intensify drowsiness and impair psychomotor performance and next-day alertness. The risk is higher with higher doses and in older patients.
What this interaction means in plain words
Clomipramine and Daridorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Daridorexant belongs to Central Nervous System.
Why it happens
Additive CNS depression from orexin receptor antagonism and the sedative antihistaminic properties of clomipramine.
What to do
Use the lowest effective daridorexant dose and warn the patient about daytime impairment and driving. Reduce the dose if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Daridorexant
Frequently asked questions
Can I take Clomipramine with Daridorexant?
MediHelp rates the interaction as moderate. Clomipramine and Daridorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause CNS depression, so concurrent use can intensify drowsiness and impair psychomotor performance and next-day alertness. The risk is higher with higher doses and in older patients.
How serious is the interaction between Clomipramine and Daridorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective daridorexant dose and warn the patient about daytime impairment and driving. Reduce the dose if excessive sedation occurs.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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