Drug interactions
Clomipramine + Darunavir
Severity: Moderate
Clomipramine and Darunavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually given with ritonavir or cobicistat, inhibits CYP3A4 and CYP2D6 (via the booster), which may increase clomipramine exposure. Higher levels raise the risk of anticholinergic effects, seizures and arrhythmia.
What this interaction means in plain words
Clomipramine and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Darunavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 (and CYP2D6 by the booster) reduces clomipramine metabolism.
What to do
Start clomipramine at a low dose and titrate to response while monitoring for toxicity. Consider an ECG and plasma level monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Clomipramine with Darunavir?
MediHelp rates the interaction as moderate. Clomipramine and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, usually given with ritonavir or cobicistat, inhibits CYP3A4 and CYP2D6 (via the booster), which may increase clomipramine exposure. Higher levels raise the risk of anticholinergic effects, seizures and arrhythmia.
How serious is the interaction between Clomipramine and Darunavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start clomipramine at a low dose and titrate to response while monitoring for toxicity. Consider an ECG and plasma level monitoring.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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