Drug interactions
Clomipramine + Dasatinib
Severity: Moderate
Clomipramine and Dasatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib can prolong the QT interval, and clomipramine also carries a risk of QT prolongation and arrhythmia. Dasatinib is a weak CYP3A4 inhibitor, so any pharmacokinetic increase in clomipramine is probably small.
What this interaction means in plain words
Clomipramine and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Dasatinib belongs to Oncology.
Why it happens
Additive QT prolongation, with possible minor CYP3A4 inhibition by dasatinib.
What to do
Check baseline ECG and electrolytes, and repeat the ECG during combined therapy. Choose a non-QT-prolonging antidepressant if the QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Clomipramine with Dasatinib?
MediHelp rates the interaction as moderate. Clomipramine and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib can prolong the QT interval, and clomipramine also carries a risk of QT prolongation and arrhythmia. Dasatinib is a weak CYP3A4 inhibitor, so any pharmacokinetic increase in clomipramine is probably small.
How serious is the interaction between Clomipramine and Dasatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes, and repeat the ECG during combined therapy. Choose a non-QT-prolonging antidepressant if the QTc becomes prolonged.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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