Drug interactions
Clomipramine + Desflurane
Severity: Moderate
Clomipramine and Desflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics such as desflurane can prolong the QT interval and depress the CNS and circulation. In patients on clomipramine, this may add to arrhythmia risk, hypotension and prolonged sedation during anesthesia.
What this interaction means in plain words
Clomipramine and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Desflurane belongs to Central Nervous System.
Why it happens
Additive QT prolongation and CNS and cardiovascular depression.
What to do
Inform the anesthetist, obtain a baseline ECG and monitor ECG and blood pressure intraoperatively. Correct electrolyte disturbances before surgery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clomipramine and Desflurane, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Desflurane
Frequently asked questions
Can I take Clomipramine with Desflurane?
MediHelp rates the interaction as moderate. Clomipramine and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volatile anesthetics such as desflurane can prolong the QT interval and depress the CNS and circulation. In patients on clomipramine, this may add to arrhythmia risk, hypotension and prolonged sedation during anesthesia.
How serious is the interaction between Clomipramine and Desflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthetist, obtain a baseline ECG and monitor ECG and blood pressure intraoperatively. Correct electrolyte disturbances before surgery.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
