Drug interactions
Clomipramine + Dexmedetomidine
Severity: Moderate
Clomipramine and Dexmedetomidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexmedetomidine is a sedative alpha-2 agonist that may add to the sedative effects of clomipramine. Both can also cause hypotension and bradycardia or arrhythmia.
What this interaction means in plain words
Clomipramine and Dexmedetomidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Dexmedetomidine belongs to Central Nervous System.
Why it happens
Additive CNS depression and hemodynamic effects.
What to do
Titrate dexmedetomidine to effect, with a lower initial dose where needed, and monitor blood pressure, heart rate and sedation depth.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Dexmedetomidine
Frequently asked questions
Can I take Clomipramine with Dexmedetomidine?
MediHelp rates the interaction as moderate. Clomipramine and Dexmedetomidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexmedetomidine is a sedative alpha-2 agonist that may add to the sedative effects of clomipramine. Both can also cause hypotension and bradycardia or arrhythmia.
How serious is the interaction between Clomipramine and Dexmedetomidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate dexmedetomidine to effect, with a lower initial dose where needed, and monitor blood pressure, heart rate and sedation depth.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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