Drug interactions
Clomipramine + Dicyclomine
Severity: Moderate
Clomipramine and Dicyclomine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine is a tricyclic antidepressant with marked anticholinergic properties. Combined with dicyclomine it can produce excessive anticholinergic effects including constipation, urinary retention, tachycardia, confusion and, in severe cases, paralytic ileus.
What this interaction means in plain words
Clomipramine and Dicyclomine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Dicyclomine belongs to Respiratory.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for anticholinergic toxicity, especially in older patients or those with prostatic enlargement or glaucoma; reduce dose or choose a non-anticholinergic alternative if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clomipramine and Dicyclomine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Dicyclomine?
MediHelp rates the interaction as moderate. Clomipramine and Dicyclomine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine is a tricyclic antidepressant with marked anticholinergic properties. Combined with dicyclomine it can produce excessive anticholinergic effects including constipation, urinary retention, tachycardia, confusion and, in severe cases, paralytic ileus.
How serious is the interaction between Clomipramine and Dicyclomine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially in older patients or those with prostatic enlargement or glaucoma; reduce dose or choose a non-anticholinergic alternative if symptoms occur.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
