Drug interactions
Clomipramine + Difelikefalin
Severity: Moderate
Clomipramine and Difelikefalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin can cause somnolence and dizziness, and clomipramine is also sedating, so combined use may increase drowsiness and fall risk.
What this interaction means in plain words
Clomipramine and Difelikefalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Difelikefalin belongs to Dermatology.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for excessive sedation and dizziness, particularly in dialysis patients who are prone to falls. Reduce the dose of one agent if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Clomipramine with Difelikefalin?
MediHelp rates the interaction as moderate. Clomipramine and Difelikefalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difelikefalin can cause somnolence and dizziness, and clomipramine is also sedating, so combined use may increase drowsiness and fall risk.
How serious is the interaction between Clomipramine and Difelikefalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and dizziness, particularly in dialysis patients who are prone to falls. Reduce the dose of one agent if symptoms occur.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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