Drug interactions
Clomipramine + Eliglustat
Severity: Major
Clomipramine and Eliglustat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat is metabolized mainly by CYP2D6, and clomipramine inhibits CYP2D6 while also being a substrate. Higher eliglustat levels raise the risk of PR, QRS, and QT prolongation, and both drugs affect cardiac conduction.
What this interaction means in plain words
Clomipramine and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clomipramine belongs to Central Nervous System; Eliglustat belongs to Miscellaneous.
Why it happens
CYP2D6 inhibition by clomipramine raises eliglustat exposure, with additive effects on cardiac conduction.
What to do
Avoid if possible; if used, reduce eliglustat dose as per labeling and monitor ECG. Consider an antidepressant with less CYP2D6 and conduction effect.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Clomipramine with Eliglustat?
MediHelp rates the interaction as major. Clomipramine and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eliglustat is metabolized mainly by CYP2D6, and clomipramine inhibits CYP2D6 while also being a substrate. Higher eliglustat levels raise the risk of PR, QRS, and QT prolongation, and both drugs affect cardiac conduction.
How serious is the interaction between Clomipramine and Eliglustat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if used, reduce eliglustat dose as per labeling and monitor ECG. Consider an antidepressant with less CYP2D6 and conduction effect.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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