Drug interactions
Clomipramine + Eslicarbazepine
Severity: Moderate
Clomipramine and Eslicarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine inhibits CYP2C19, which demethylates clomipramine, so clomipramine levels may rise and the active metabolite proportion may change. Higher exposure could increase anticholinergic, cardiac and seizure risks. Eslicarbazepine also has weak inducing effects on other enzymes.
What this interaction means in plain words
Clomipramine and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Eslicarbazepine belongs to Central Nervous System.
Why it happens
CYP2C19 inhibition by eslicarbazepine decreases clomipramine metabolism.
What to do
Monitor for tricyclic adverse effects and consider checking plasma levels. Adjust the clomipramine dose according to response and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Clomipramine with Eslicarbazepine?
MediHelp rates the interaction as moderate. Clomipramine and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine inhibits CYP2C19, which demethylates clomipramine, so clomipramine levels may rise and the active metabolite proportion may change. Higher exposure could increase anticholinergic, cardiac and seizure risks. Eslicarbazepine also has weak inducing effects on other enzymes.
How serious is the interaction between Clomipramine and Eslicarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and consider checking plasma levels. Adjust the clomipramine dose according to response and tolerability.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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