Drug interactions
Clomipramine + Fosaprepitant
Severity: Minor
Clomipramine and Fosaprepitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosaprepitant is converted to aprepitant, a moderate CYP3A4 inhibitor. Clomipramine is partly metabolized by CYP3A4, so levels may rise modestly, though a single-dose course usually has a limited effect.
What this interaction means in plain words
Clomipramine and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clomipramine belongs to Central Nervous System; Fosaprepitant belongs to Gastrointestinal Tract.
Why it happens
Aprepitant, the active form of fosaprepitant, transiently inhibits CYP3A4-mediated metabolism of clomipramine.
What to do
No dose change is usually needed for a single dose. Watch for anticholinergic, sedative or cardiac effects if repeated dosing is given.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Fosaprepitant
- Flibanserin + Fosaprepitant Contraindicated
- Fosaprepitant + Pimozide Contraindicated
- Alprazolam + Fosaprepitant Moderate
- Amiodarone + Fosaprepitant Moderate
- Amobarbital + Fosaprepitant Moderate
- Apalutamide + Fosaprepitant Moderate
Frequently asked questions
Can I take Clomipramine with Fosaprepitant?
MediHelp rates the interaction as minor. Clomipramine and Fosaprepitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosaprepitant is converted to aprepitant, a moderate CYP3A4 inhibitor. Clomipramine is partly metabolized by CYP3A4, so levels may rise modestly, though a single-dose course usually has a limited effect.
How serious is the interaction between Clomipramine and Fosaprepitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed for a single dose. Watch for anticholinergic, sedative or cardiac effects if repeated dosing is given.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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