Drug interactions
Clomipramine + Granisetron
Severity: Moderate
Clomipramine and Granisetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine is strongly serotonergic and can prolong the QT interval. Granisetron adds a small QT effect, and serotonin syndrome is possible.
What this interaction means in plain words
Clomipramine and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Granisetron belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation and possible additive serotonergic effects.
What to do
Check an ECG and electrolytes in patients with cardiac risk factors. Monitor for serotonin toxicity and stop the drugs if it appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Granisetron?
MediHelp rates the interaction as moderate. Clomipramine and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine is strongly serotonergic and can prolong the QT interval. Granisetron adds a small QT effect, and serotonin syndrome is possible.
How serious is the interaction between Clomipramine and Granisetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG and electrolytes in patients with cardiac risk factors. Monitor for serotonin toxicity and stop the drugs if it appears.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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