Drug interactions
Clomipramine + Haloperidol
Severity: Major
Clomipramine and Haloperidol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol inhibits CYP2D6 and can raise clomipramine concentrations, while both drugs prolong the QT interval. Together this increases the risk of arrhythmia, sedation and anticholinergic toxicity.
What this interaction means in plain words
Clomipramine and Haloperidol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clomipramine belongs to Central Nervous System; Haloperidol belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by haloperidol increases clomipramine exposure, with additive QT prolongation.
What to do
Avoid if possible; otherwise monitor ECG and electrolytes, consider tricyclic plasma levels, and reduce the clomipramine dose if toxicity appears.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Clomipramine with Haloperidol?
MediHelp rates the interaction as major. Clomipramine and Haloperidol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Haloperidol inhibits CYP2D6 and can raise clomipramine concentrations, while both drugs prolong the QT interval. Together this increases the risk of arrhythmia, sedation and anticholinergic toxicity.
How serious is the interaction between Clomipramine and Haloperidol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor ECG and electrolytes, consider tricyclic plasma levels, and reduce the clomipramine dose if toxicity appears.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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