Drug interactions
Clomipramine + Iloprost
Severity: Moderate
Clomipramine and Iloprost: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloprost is a potent vasodilator and clomipramine can cause orthostatic hypotension through alpha-adrenergic blockade. Combined use may cause additive hypotension, dizziness and falls.
What this interaction means in plain words
Clomipramine and Iloprost can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Iloprost belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from prostacyclin-mediated vasodilation and alpha-1 blockade by clomipramine.
What to do
Monitor blood pressure during iloprost initiation and dose increases. Reduce the iloprost dose if symptomatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Iloprost
- Aldesleukin + Iloprost Moderate
- Amiodarone + Iloprost Moderate
- Bortezomib + Iloprost Moderate
- Bromocriptine + Iloprost Moderate
- Bupivacaine + Iloprost Moderate
- Carbidopa-entacapone-levodopa + Iloprost Moderate
Frequently asked questions
Can I take Clomipramine with Iloprost?
MediHelp rates the interaction as moderate. Clomipramine and Iloprost can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloprost is a potent vasodilator and clomipramine can cause orthostatic hypotension through alpha-adrenergic blockade. Combined use may cause additive hypotension, dizziness and falls.
How serious is the interaction between Clomipramine and Iloprost?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during iloprost initiation and dose increases. Reduce the iloprost dose if symptomatic hypotension develops.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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