Drug interactions
Clomipramine + Lasmiditan
Severity: Moderate
Clomipramine and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and cognitive impairment, so combined use may deepen sedation and impair psychomotor performance. Clomipramine is a potent serotonin reuptake inhibitor, and serotonin syndrome is a theoretical concern with a 5-HT1F agonist, although lasmiditan lacks vasoconstrictive 5-HT1B/1D activity.
What this interaction means in plain words
Clomipramine and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Lasmiditan belongs to Central Nervous System.
Why it happens
Additive CNS depression, plus a theoretical additive serotonergic effect that is not well established.
What to do
Counsel patients to avoid driving for at least 8 hours after lasmiditan and to avoid other sedatives. Monitor for agitation, tremor, hyperthermia or clonus after dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clomipramine and Lasmiditan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Clomipramine with Lasmiditan?
MediHelp rates the interaction as moderate. Clomipramine and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness and cognitive impairment, so combined use may deepen sedation and impair psychomotor performance. Clomipramine is a potent serotonin reuptake inhibitor, and serotonin syndrome is a theoretical concern with a 5-HT1F agonist, although lasmiditan lacks vasoconstrictive 5-HT1B/1D activity.
How serious is the interaction between Clomipramine and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving for at least 8 hours after lasmiditan and to avoid other sedatives. Monitor for agitation, tremor, hyperthermia or clonus after dosing.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
