Drug interactions
Clomipramine + Lornoxicam
Severity: Moderate
Clomipramine and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine impairs platelet serotonin uptake, which reduces platelet aggregation, while lornoxicam inhibits platelet function and damages gastric mucosa. Together the risk of gastrointestinal bleeding is increased.
What this interaction means in plain words
Clomipramine and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Lornoxicam belongs to Musculoskeletal.
Why it happens
Additive impairment of platelet function by serotonin reuptake inhibition and NSAID cyclo-oxygenase inhibition.
What to do
Use the lowest NSAID dose for the shortest time and consider gastroprotection with a proton pump inhibitor in at-risk patients. Advise patients to report black stools or abdominal pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Lornoxicam
Frequently asked questions
Can I take Clomipramine with Lornoxicam?
MediHelp rates the interaction as moderate. Clomipramine and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine impairs platelet serotonin uptake, which reduces platelet aggregation, while lornoxicam inhibits platelet function and damages gastric mucosa. Together the risk of gastrointestinal bleeding is increased.
How serious is the interaction between Clomipramine and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest NSAID dose for the shortest time and consider gastroprotection with a proton pump inhibitor in at-risk patients. Advise patients to report black stools or abdominal pain.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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