Drug interactions
Clomipramine + Lurasidone
Severity: Moderate
Clomipramine and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause orthostatic hypotension and sedation through alpha-1 blockade. Combined use may produce dizziness and falls, particularly in older patients or those on antihypertensives. Clomipramine may also affect cardiac conduction.
What this interaction means in plain words
Clomipramine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Additive alpha-1 adrenergic blockade and CNS depressant effects.
What to do
Monitor blood pressure and orthostatic symptoms, particularly when starting or titrating either drug. Adjust antihypertensive therapy if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Clomipramine with Lurasidone?
MediHelp rates the interaction as moderate. Clomipramine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause orthostatic hypotension and sedation through alpha-1 blockade. Combined use may produce dizziness and falls, particularly in older patients or those on antihypertensives. Clomipramine may also affect cardiac conduction.
How serious is the interaction between Clomipramine and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, particularly when starting or titrating either drug. Adjust antihypertensive therapy if hypotension occurs.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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