Drug interactions
Clomipramine + Mefenamic acid
Severity: Moderate
Clomipramine and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine, a strongly serotonergic tricyclic, can impair platelet function and when combined with mefenamic acid increases gastrointestinal bleeding risk. The effect is similar to that seen with SSRIs and NSAIDs.
What this interaction means in plain words
Clomipramine and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Mefenamic acid belongs to Musculoskeletal.
Why it happens
Inhibition of platelet serotonin uptake combined with NSAID-induced platelet inhibition and mucosal injury produces additive bleeding risk.
What to do
Use the shortest NSAID course possible and consider proton pump inhibitor gastroprotection in high-risk patients. Monitor for signs of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Mefenamic acid?
MediHelp rates the interaction as moderate. Clomipramine and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine, a strongly serotonergic tricyclic, can impair platelet function and when combined with mefenamic acid increases gastrointestinal bleeding risk. The effect is similar to that seen with SSRIs and NSAIDs.
How serious is the interaction between Clomipramine and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the shortest NSAID course possible and consider proton pump inhibitor gastroprotection in high-risk patients. Monitor for signs of GI bleeding.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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