Drug interactions
Clomipramine + Methylphenidate
Severity: Moderate
Clomipramine and Methylphenidate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylphenidate may inhibit the metabolism of tricyclic antidepressants and raise their concentrations. Both drugs also increase noradrenergic activity, which may cause tachycardia, hypertension, agitation and arrhythmias.
What this interaction means in plain words
Clomipramine and Methylphenidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Methylphenidate belongs to Central Nervous System.
Why it happens
Possible inhibition of tricyclic metabolism and additive noradrenergic and cardiovascular stimulation.
What to do
Monitor blood pressure, heart rate and signs of tricyclic toxicity, and consider reducing the clomipramine dose or checking serum levels. Use caution in patients with cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Methylphenidate
- Isocarboxazid + Methylphenidate Contraindicated
- Linezolid + Methylphenidate Contraindicated
- Methylphenidate + Phenelzine Contraindicated
- Methylphenidate + Procarbazine Contraindicated
- Methylphenidate + Rasagiline Contraindicated
- Methylphenidate + Safinamide Contraindicated
Frequently asked questions
Can I take Clomipramine with Methylphenidate?
MediHelp rates the interaction as moderate. Clomipramine and Methylphenidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methylphenidate may inhibit the metabolism of tricyclic antidepressants and raise their concentrations. Both drugs also increase noradrenergic activity, which may cause tachycardia, hypertension, agitation and arrhythmias.
How serious is the interaction between Clomipramine and Methylphenidate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and signs of tricyclic toxicity, and consider reducing the clomipramine dose or checking serum levels. Use caution in patients with cardiac disease.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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