Drug interactions
Clomipramine + Mirabegron
Severity: Moderate
Clomipramine and Mirabegron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirabegron is a moderate inhibitor of CYP2D6 and can raise plasma concentrations of clomipramine, which is partly cleared by this enzyme. Higher exposure may increase anticholinergic effects, sedation, cardiac conduction effects and seizure risk.
What this interaction means in plain words
Clomipramine and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Mirabegron belongs to Genitourinary.
Why it happens
Mirabegron inhibits CYP2D6, reducing the metabolism of clomipramine and its active metabolite.
What to do
Monitor for tricyclic adverse effects and consider an ECG or serum level check in higher-risk patients. Reduce the clomipramine dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Mirabegron?
MediHelp rates the interaction as moderate. Clomipramine and Mirabegron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mirabegron is a moderate inhibitor of CYP2D6 and can raise plasma concentrations of clomipramine, which is partly cleared by this enzyme. Higher exposure may increase anticholinergic effects, sedation, cardiac conduction effects and seizure risk.
How serious is the interaction between Clomipramine and Mirabegron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and consider an ECG or serum level check in higher-risk patients. Reduce the clomipramine dose if toxicity appears.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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