Drug interactions
Clomipramine + Nabilone
Severity: Moderate
Clomipramine and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine is a sedating tricyclic antidepressant with anticholinergic and cardiovascular effects, and nabilone adds drowsiness and tachycardia. The combination may increase sedation, tachycardia and orthostatic symptoms.
What this interaction means in plain words
Clomipramine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive central nervous system depression and additive tachycardic and anticholinergic effects through pharmacodynamic synergy.
What to do
Monitor sedation, heart rate and blood pressure, especially when starting or increasing either drug. Use caution in patients with cardiac disease or older age and advise avoiding alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Nabilone?
MediHelp rates the interaction as moderate. Clomipramine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine is a sedating tricyclic antidepressant with anticholinergic and cardiovascular effects, and nabilone adds drowsiness and tachycardia. The combination may increase sedation, tachycardia and orthostatic symptoms.
How serious is the interaction between Clomipramine and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, heart rate and blood pressure, especially when starting or increasing either drug. Use caution in patients with cardiac disease or older age and advise avoiding alcohol.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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