Drug interactions
Clomipramine + Nabumetone
Severity: Moderate
Clomipramine and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine, a potent serotonin reuptake inhibitor, combined with nabumetone raises the risk of gastrointestinal and other bleeding. The risk is greater in older patients and those with a history of ulcers.
What this interaction means in plain words
Clomipramine and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Nabumetone belongs to Musculoskeletal.
Why it happens
Reduced platelet serotonin uptake impairs platelet aggregation, adding to NSAID platelet inhibition and mucosal injury.
What to do
Use the lowest effective NSAID dose for the shortest duration and consider gastroprotection with a proton pump inhibitor in higher-risk patients. Advise patients to report signs of bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Nabumetone?
MediHelp rates the interaction as moderate. Clomipramine and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine, a potent serotonin reuptake inhibitor, combined with nabumetone raises the risk of gastrointestinal and other bleeding. The risk is greater in older patients and those with a history of ulcers.
How serious is the interaction between Clomipramine and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest duration and consider gastroprotection with a proton pump inhibitor in higher-risk patients. Advise patients to report signs of bleeding.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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