Drug interactions
Clomipramine + Omeprazole
Severity: Moderate
Clomipramine and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine is partly demethylated by CYP2C19, so omeprazole may raise clomipramine levels. Increased anticholinergic, sedative or cardiac effects are possible, particularly in CYP2C19 poor metabolizers.
What this interaction means in plain words
Clomipramine and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Omeprazole inhibits CYP2C19-mediated metabolism of clomipramine.
What to do
Monitor for tricyclic adverse effects and consider checking drug levels or ECG if symptoms arise. Reduce the clomipramine dose if needed or choose a different acid suppressant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Omeprazole?
MediHelp rates the interaction as moderate. Clomipramine and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine is partly demethylated by CYP2C19, so omeprazole may raise clomipramine levels. Increased anticholinergic, sedative or cardiac effects are possible, particularly in CYP2C19 poor metabolizers.
How serious is the interaction between Clomipramine and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects and consider checking drug levels or ECG if symptoms arise. Reduce the clomipramine dose if needed or choose a different acid suppressant.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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