Drug interactions
Clomipramine + Phentermine
Severity: Major
Clomipramine and Phentermine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentermine releases norepinephrine, and clomipramine can potentiate sympathomimetic effects while also adding serotonergic activity. This may cause hypertension, tachycardia, arrhythmias or serotonin toxicity.
What this interaction means in plain words
Clomipramine and Phentermine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clomipramine belongs to Central Nervous System; Phentermine belongs to Central Nervous System.
Why it happens
Additive noradrenergic and serotonergic effects from catecholamine release and reuptake inhibition.
What to do
Avoid the combination if possible. If used, monitor blood pressure, heart rate and signs of serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Phentermine
- Isocarboxazid + Phentermine Contraindicated
- Linezolid + Phentermine Contraindicated
- Phenelzine + Phentermine Contraindicated
- Phentermine + Procarbazine Contraindicated
- Phentermine + Rasagiline Contraindicated
- Phentermine + Selegiline Contraindicated
Frequently asked questions
Can I take Clomipramine with Phentermine?
MediHelp rates the interaction as major. Clomipramine and Phentermine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phentermine releases norepinephrine, and clomipramine can potentiate sympathomimetic effects while also adding serotonergic activity. This may cause hypertension, tachycardia, arrhythmias or serotonin toxicity.
How serious is the interaction between Clomipramine and Phentermine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If used, monitor blood pressure, heart rate and signs of serotonin toxicity.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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