Drug interactions
Clomipramine + Piroxicam
Severity: Moderate
Clomipramine and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clomipramine strongly inhibits serotonin reuptake, so with an NSAID it can increase the likelihood of upper gastrointestinal bleeding. The effect resembles that seen with SSRIs.
What this interaction means in plain words
Clomipramine and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Piroxicam belongs to Musculoskeletal.
Why it happens
Reduced platelet serotonin uptake impairs platelet aggregation, adding to NSAID mucosal injury and platelet inhibition.
What to do
Consider gastroprotection with a proton pump inhibitor in at-risk patients and keep NSAID exposure short. Monitor for signs of GI bleeding or anemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Clomipramine with Piroxicam?
MediHelp rates the interaction as moderate. Clomipramine and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clomipramine strongly inhibits serotonin reuptake, so with an NSAID it can increase the likelihood of upper gastrointestinal bleeding. The effect resembles that seen with SSRIs.
How serious is the interaction between Clomipramine and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider gastroprotection with a proton pump inhibitor in at-risk patients and keep NSAID exposure short. Monitor for signs of GI bleeding or anemia.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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