Drug interactions
Clomipramine + Ribociclib
Severity: Major
Clomipramine and Ribociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib prolongs the QT interval in a dose-dependent manner, and clomipramine adds to this effect, raising the risk of torsades de pointes. Ribociclib also inhibits CYP3A4, which may further affect exposure to some co-medications.
What this interaction means in plain words
Clomipramine and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clomipramine belongs to Central Nervous System; Ribociclib belongs to Oncology.
Why it happens
Additive QT prolongation, with possible pharmacokinetic increase in tricyclic levels.
What to do
Avoid if possible; if combined, monitor ECG and electrolytes at baseline and during treatment and interrupt or reduce ribociclib if QTc becomes prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Clomipramine with Ribociclib?
MediHelp rates the interaction as major. Clomipramine and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ribociclib prolongs the QT interval in a dose-dependent manner, and clomipramine adds to this effect, raising the risk of torsades de pointes. Ribociclib also inhibits CYP3A4, which may further affect exposure to some co-medications.
How serious is the interaction between Clomipramine and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if combined, monitor ECG and electrolytes at baseline and during treatment and interrupt or reduce ribociclib if QTc becomes prolonged.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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