Drug interactions
Clomipramine + Rosiglitazone
Severity: Minor
Clomipramine and Rosiglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may modestly alter glycemic control, so glucose-lowering effects of rosiglitazone could occasionally be enhanced. Clinical significance is unknown and reports are limited.
What this interaction means in plain words
Clomipramine and Rosiglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clomipramine belongs to Central Nervous System; Rosiglitazone belongs to Endocrine.
Why it happens
Possible additive pharmacodynamic effect on glucose regulation; not well established.
What to do
Monitor blood glucose when starting or stopping clomipramine in a patient on rosiglitazone, and adjust diabetes therapy only if glucose changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Clomipramine with Rosiglitazone?
MediHelp rates the interaction as minor. Clomipramine and Rosiglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants may modestly alter glycemic control, so glucose-lowering effects of rosiglitazone could occasionally be enhanced. Clinical significance is unknown and reports are limited.
How serious is the interaction between Clomipramine and Rosiglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping clomipramine in a patient on rosiglitazone, and adjust diabetes therapy only if glucose changes.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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